Sumatriptan pregnancy

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Sumatriptan Pregnancy Warnings Animal studies have revealed evidence of embryolethality, fetal abnormalities (decreased ossification, skeletal abnormalities, cervicothoracic vascular defects), decreased fetal body weight, and pup mortality Sumatriptan (Imitrex®, Imigran®) is a medication used to treat migraine headaches. It can be used orally (pill), by nasal spray or by injection (shot). Sumatriptan is also available in a combination product (Treximet®) that also contains naproxen. Naproxen containing products are best to avoid during late pregnancy sumatriptan was used during pregnancy.* Does taking sumatriptan increase the chance of having a baby with a birth defect? In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. Overall, the studies have not found an increase in the chance of birth defects when. When compellingly needed during pregnancy, sumatriptan as the best studied triptan appears an acceptable treatment option. A detailed fetal ultrasound should be offered in cases of first trimester exposure to less well-studied triptans. Trial registration number in German Clinical Trials Register: DRKS00007660

Sumatriptan Use During Pregnancy Drugs

  1. The accumulated evidence from sumatriptan's pregnancy registry and other studies suggest that this drug is a safe therapeutic option for the treatment of migraine attacks in pregnant women. More studies are needed to confirm the safety of the other triptans in pregnancy; however, evidence to date is reassuring
  2. The accumulated evidence from sumatriptan's pregnancy registry and other studies suggest that this drug is a safe therapeutic option for the treatment of migraine attacks in pregnant women. More studies are needed to confirm the safety of the other triptans in pregnancy; however, evidence to date is reassuring..
  3. e (DHE) as a rescue treatment for their migraines
  4. Sumatriptan (Imitrex) was first introduced 20 years ago and a registry of women who took sumatriptan during pregnancy suggests that this is a safe drug. Pregnancy registry for rizatriptan (Maxalt), which is the second triptan to come to the market 15 years ago, also suggests that it is a safe drug
Pharmacotherapy for Primary Headache Disorders in the

Sumatriptan - MotherToBab

  1. After pregnancy, most medications are passed on to the infant in breast milk in varying degrees. Some acute medications such as sumatriptan can be used while nursing. Discussion concerning the pros and cons of all migraine medications is recommended between providers and women who may become pregnant, are pregnant, or are nursing. Deborah.
  2. The Registry documented outcomes of 626 infants and fetuses exposed to Sumatriptan during pregnancy (528 with earliest exposure during the first trimester, 78 during the second trimester, 16 during the third trimester, and 4 unknown)
  3. The available data (including a collective total of ~11,000 pregnancies with exposure to any triptan and >9,000 sumatriptan-exposed pregnancies) do not raise concern of an increased risk of congenital malformation following in utero exposure
  4. Headache in pregnant and postpartum women triptan exposure during pregnancy primarily involves sumatriptan and has been generally reassuring. A manufacturer pregnancy registry for sumatriptan exposure during pregnancy did not find an increased Pathophysiology, clinical features, and diagnosis of migraine in childre
  5. The data available through pregnancy registries for sumatriptan states that spontaneous abortion is the most common adverse effect. However, your doctor might prescribe the drug during pregnancy if they deem it necessary (6). What Are The Side Effects of Imitrex During Pregnancy? Imitrex might have the following side-effects (7)
  6. A baby's body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects. Studies of a total of around 3,000 pregnant women taking sumatriptan do not raise concern of a link with birth defects in the baby
  7. g, dose and duration of the drug exposure, estimated date of delivery, and sufficient contact information to allow for follow-up of the subsequent pregnancy outcome. Measures are in place to protect patient confidentiality

  1. When the triptans were introduced in 1990 (sumatriptan was the first one), the label stated that these drugs are contraindicated during pregnancy. This labeling occurred despite the fact that..
  2. Our findings support the evidence that triptans are not major teratogens. When compellingly needed during pregnancy, sumatriptan as the best studied triptan appears an acceptable treatment..
  3. Sumatriptan is a prescription-only migraine medication available in the UK. For many people, it is an extremely effective and fast-acting treatment that tackles migraine symptoms and pain head-on. But is it safe to use if you are pregnant? On this page, we'll be answering some common questions about taking Sumatriptan to treat migraines during pregnancy — read on to find out more
  4. ophen taken during pregnancy and negative effects on babies are weak at best. For that reason, the author writes, Aceta
  5. The Sumatriptan Pregnancy Registry was established by GlaxoSmithKline (GSK) in 1996 to monitor the safety of sumatriptan during pregnancy. It was combined with the Naratriptan Pregnancy Registry in 2001 and data collection on the sumatriptan-naproxen combination (Treximet) began in 2008
  6. The Sumatriptan and Naratriptan Pregnancy Registry captures data on women exposed to those drugs during pregnancy to monitor for evidence of major teratogenicity. Methods.— Healthcare professionals from anywhere in the world can enroll, on a voluntary basis, women exposed to sumatriptan or naratriptan during their pregnancies in this.

Data from a prospective pregnancy exposure registry and epidemiological studies of pregnant women have not detected increased frequency of birth defects or consistent pattern of birth defects among women exposed to sumatriptan compared with general population; in developmental toxicity studies in rats and rabbits, oral administration of. Sumatriptan is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea or sensitivity to sound and light). Sumatriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the head, stopping pain signals from being sent to.

Pregnancy outcome after anti-migraine triptan use: A

  1. istration contains 35, 70, or 140 mg of sumatriptan 16 succinate equivalent to 25, 50, or 100 mg of sumatriptan, respectively. Each tablet also contain
  2. Sumatriptan is not thought to be harmful during pregnancy, but there is not enough research to say for certain. Talk to a doctor about the benefits and possible harms of taking sumatriptan. There may be other medicines that are safer for you
  3. Impact of Sumatriptan during pregnancy on fetal development, risk of stillbirth, malformation or birth defects. Systematic review and meta-analysis of studie
  4. Prospective collection of pregnancy exposure and outcome data is one method for providing data to the medical community as a tool for making risk assessments.Methods: The Sumatriptan Pregnancy Registry is an international, exposure-registration and follow-up study to prospectively collect prenatal sumatriptan exposure and outcome data
  5. ed. 1. Pharmacological Effects of the Triptans

Feb 2, 2017 at 2:54 AM. No, my doctor and midwife said it is definitely not safe during pregnancy. I've had migraines for years that only go away with sumatriptan/imitrex. What has surprisingly worked for me now is a hot cup of coffee, 2 pills of Tylenol extra strength, and a nap if I can. The triptans, most experts agree, are the go-to drugs for frequent or serious migraines in pregnancy. And in a situation where women are very ill, I will use injectable sumatriptan. There are. Acetaminophen is commonly used as an abortive agent for migraine and is considered safe during all trimesters of pregnancy. Acetominophen use is reported by 65% of pregnant women. 35 There was some concern of an association between acetaminophen use during pregnancy and neurodevelopment effects, (eg, attention deficit hyperactivity disorder. Some of the most common effects of taking sumatriptan, or Imitrex during pregnancy can cause; a low weight of the baby at birth, preterm labor, and delivery, as well as some anomalies in the fetus that may or may not be minor. According to various animal studies conducted on the effects of sumatriptan, or Imitrex, the unborn child, it was found. Pregnancy can have a significant impact on migraine symptoms and how women should treat them. Here's what experts have to say. First, the good news: Between 50 and 80% of pregnant migraine patients actually experience a reduction in migraine attacks during their pregnancy, according to David Dodick, a professor of medicine at the Mayo Clinic.

Triptan 2,3 - Sumatriptan is the preferred triptan in pregnancy and breastfeeding because there has been more experience of its use. A few large pregnancy registries covering more than 3,000 pregnancies, have analysed the use of other triptans, (including rizatriptan, zolmitriptan and eletriptan) and found no major congenital defects Pregnancy Post-marketing data on the use of sumatriptan during the first trimester of pregnancy in over 1,000 women are available. Although these data contain insufficient information to draw definitive conclusions, they do not point to an increased risk of congential defects represented in two separate registries - the Sumatriptan Pregnancy Registry and the Naratriptan Pregnancy Registry. Since April 2001, the Registries have been combined. In June 2008, Treximet was added to the Sumatriptan and Naratriptan Pregnancy Registry. There were 9 reports of exposure to both sumatriptan and naratriptan (two o Data have been collected in areas including placental transmission of sumatriptan, prospective pregnancy registries, open-labeled and controlled prospective studies, and a retrospective prescription-linked study. As of August 6, 2004, no randomized controlled trials have been conducted with exposure to sumatriptan during pregnancy Data regarding safety of sumatriptan during pregnancy are reassuring.11 However, continuing triptans during pregnancy is not recommended without medical supervision. ā Ergots Ergotamine should not be used during pregnancy as it can increase the risk of miscarriage and perinatal death. Drugs to prevent migrain

The safety of sumatriptan during pregnancy hasn't been established and it should only be used during pregnancy if the potential benefits outweigh any potential risks to the baby In offspring of pregnant rats treated orally with sumatriptan during organogenesis, there was a decrease in pup survival. The highest no-effect dose for this effect was 60 mg/kg/day. Oral treatment of pregnant rats with sumatriptan during the latter part of gestation and throughout lactation resulted in a decrease in pup survival Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. It is taken by mouth, in the nose, or by injection under the skin. Effects generally occur within three hours. Common side effects include chest pressure, fatigue, vomiting, tingling, and the feeling that the world is spinning Pregnancy and imitrex Pregnancy is a delicate timing for the woman which needs a lot of care and attention for the lady who is in this situation. It is very important to look that what you eat and drink when you are pregnant because it directly affects you and your baby too Imitrex was given a pregnancy Category C rating based on studies in pregnant animals. For example, when Imitrex was given to pregnant rabbits during early pregnancy, there was an increase in deaths of the developing embryo. This risk was not seen when Imitrex was tested on rats

a low supply of oxygen rich blood to the heart. a stroke. cerebral ischemia, a lack of blood supply to the brain. peripheral vascular disease. an ischemic bowel, a condition where the blood flow. 21 IMITREX (sumatriptan succinate) Injection, additional single IMITREX Tablets (up to 22 100 mg/day) may be given with an interval of at least 2 hours between tablet doses. 23 The safety of treating an average of more than 4 headaches in a 30-day period has not 24 . been established. 25 . 2.2 Dosing in Patients With Hepatic Impairmen Background: Sumatriptan is an acute treatment for migraine which is often used by women in their child-bearing years, and who become unexpectedly pregnant. Within the context of the post-marketing use of sumatriptan injection for the acute treatment of migraine, and in compliance with approved labeling, we wished to compare perinatal pregnancy outcomes in women who did and did not use the drug. Sumatriptan oral tablet is a prescription drug that's available as the brand-name drug Imitrex.It's also available as a generic drug. Generic drugs usually cost less

Sumatriptan - The subcutaneous, oral, and intranasal preparations of sumatriptan have proven efficacy in randomized placebo-controlled trials of acute migraine therapy, as established in systematic reviews and meta-analyses . • Oral sumatriptan is given at 50 to 100 mg once Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches. The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste Sumatriptan is the preferred triptan in pregnancy and breastfeeding — seek specialist advice if unsure or the infant is pre-term, of low birth weight, or has other medical problems. Do NOT prescribe aspirin or opiates for migraine in pregnant or breastfeeding women Use of sumatriptan and naproxen combination is not recommended in elderly patients with kidney problems, heart and blood vessel disease, or high blood pressure. Breastfeeding . There are no adequate studies in women for determining infant risk when using this medication during breastfeeding The patent on Imitrex STATDose expired in December 2006, and injectable sumatriptan became available as a generic formula in August 2008. [citation needed] Sumavel Dosepro is a needle-free delivery of injectable sumatriptan that was approved in the US by the FDA in July 2009. Sumatriptan became available as a generic in the US in late 2009

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I also took sumatriptan at 17 weeks pregnant after a 3 day migraine that I just couldn't cope with any longer. I was becoming seriously dehydrated and I was worried how that might affect the baby. I spoke to my gp surgery and they said that they advised against it as that is what the manufacturer says Chronic Migraines and Imitrex during pregnancy!!! I've suffered from severe headaches since middle school (junior high). 2 days prior to finding out about this pregnancy I finally got a chronic migraine diagnosis and was given a cocktail of medication to help alleviate the pain. I had a steroid pill, an anti inflammatory pill, nausea. before continuing with sumatriptan injections. 10. Do not use sumatriptan injection if pregnancy is suspected. Tablet: • Nausea, vomiting, malaise, and fatigue are the most common adverse effects. Nasal Spray: • Bitter taste at the back of the mouth is the primary patient complaint

Imitrex is FDA pregnancy category C, which means that it's not known whether this drug will harm an unborn baby. Be sure to speak with your doctor if you are pregnant or could become pregnant during treatment. In terms of breastfeeding, the American Academy of Pediatrics, or AAP, lists sumatriptan as compatible with breast-feeding. That being. By subcutaneous injection. For Child 10-17 years. Initially 6 mg for 1 dose, followed by 6 mg after at least 1 hour if required, to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack), dose to be administered using an auto-injector; maximum 12 mg per day


Safety of triptans for migraine headaches during pregnancy

Before taking sumatriptan. Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sumatriptan it is important that your doctor knows: If you are aged over 65 years or under 18 years. If you are pregnant or breastfeeding Imitrex is a prescription medication used to treat migraine headaches once they have started. Imitrex belongs to a group of drugs called serotonin receptor agonists or triptans, which relieve pain by narrowing blood vessels around the brain

Sumatriptan succinate USP is a white to off-white powder that is readily soluble in water and in saline. Each sumatriptan tablet, USP for oral administration contains 35 mg, 70 mg, or 140 mg of sumatriptan succinate USP equivalent to 25 mg, 50 mg, or 100 mg of sumatriptan, respectively Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and. Imitrex® (sumatriptan succinate) is a selective 5-HT1B/1D receptor agonist indicated for the acute treatment of migraine, with or without aura, in adults who have a clear migraine diagnosis.It is taken by mouth for the relief of migraine severity, from moderate or severe pain to mild or no pain Sumatriptan should not be used by pregnant or breastfeeding women without consulting a doctor first. This medicine may cause dizziness or weakness. Stay out of traffic if you experience these side effects. Alcohol is a migraine trigger. Avoid drinking alcohol shortly after a migraine attack

Infant exposure to sumatriptan can be minimized by avoiding breastfeeding for 12 hr after treatment with sumatriptan tablets. Following subcutaneous administration of a 6-mg dose of sumatriptan injection in 5 lactating volunteers, sumatriptan was present in milk. Pregnancy Categories. A: Generally acceptable Description: Sumatriptan is a selective serotonin agonist that acts at 5-HT 1 receptors. It causes vasoconstriction of cranial arteries and/or inhibition of neurogenic inflammatory processes in the CNS. A small but significant delay in gastric emptying also occurs Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Sumatriptan is a migraine headache medicine. Naproxen and sumatriptan is a combination medicine used to treat migraine headaches Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches. Fioricet (butalbital / acetaminophen / caffeine) works better and faster in treating tension headaches than the combination of acetaminophen and codeine. Fioricet (butalbital / acetaminophen / caffeine) has a. Sumatriptan was the first triptan to be developed and approved for clinical practice in patients with migraine. Sumatriptan is available in injectable, intranasal, and oral formulations. Sumatriptan has been shown to cause a decrease in plasma CGRP concentration in parallel with a reduction in pain during migraine attacks (Juhasz et al., 2005)

Pregnancy and Migraine Medications - Association of

We prospectively compared pregnancy outcome after exposure to sumatriptan with that of disease-matched controls and nonteratogen controls. There were no differences in the rates of live births, spontaneous abortions, therapeutic abortions, or major birth defects among the three groups. This first prospective report suggests that the use of sumatriptan during organogenesis is not associated. Methods: The Sumatriptan Pregnancy Registry is an international, exposure-registration and follow-up study to prospectively collect prenatal sumatriptan exposure and outcome data. An advisory committee reviews data and assists in disseminating information. Committee members include independent scientists with expertise in obstetrics, pediatrics.

Triptans are the first line migraine drugs in pregnant

Sumatriptan is in FDA pregnancy category C. This means that this medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Additionally, your name may need to be listed on a sumatriptan pregnancy registry when you start using this medication Other drugs such as sumatriptan (Imitrex), dexamethasone (brief, isolated use; avoid during the first trimester), and ketorolac (second trimester only) can be used with caution, after the. Anybody take sumatriptan for migraines during pregnancy? I'm in my second trimester and my doctor said I could it as needed, but I'm seeing mixed reviews online. 0 comments. share. save. hide. report. 100% Upvoted. Log in or sign up to leave a comment Log In Sign Up. Sort by. best. no comments yet The sumatriptan prospective pregnancy registry collected pregnancy outcomes of 528 infants and fetuses with earliest sumatriptan exposure during the first trimester, 78 during the second trimester, and 16 during the third trimester. The incidence of major birth defects during first trimester exposure was 4.2% (20/478 [95% CI 2.6% to 6.5%]) and.

Here is the FDA approved information on Imitrex. According to the label (what the FDA has approved the product for), it carries Pregnancy Category C rating. That means that data hasn't been submitted to the FDA to seek the approval. But this is an exact quote from the label, IMITREX should be used during pregnancy only if the potential benefit. Imitrex seems to be the only thing that gets rid of my headaches. Has anyone taken Imitrex while pregnant or while trying to get pregnant? I have been trying not to take any medication while trying to get pregnant for fear that it might keep me from it ### What you need to know A 36 year old woman who is 17 weeks pregnant with a 15 year history of migraine presents with an episode of a frontal unilateral headache. It is associated with nausea and visual aura consisting of mainly zigzag lines. She says that this headache is similar to her usual migraines, with two other episodes during this pregnancy so far, each lasting for about five or six.

Sumatriptan - FDA prescribing information, side effects

I don't take Imitrex because I'm intolerant of it, but I do take Relpax and Frova, which are also triptans. The concern in taking them during pregnancy used to be that they would restrict blood flow to the baby, but my doctors (I see maternal fetal due to being high risk) said that that research is old, there is no evidence of that happening, and that newer research shows that these meds are. Migraine headache medicine such as sumatriptan and opioid pain medicines such as morphine should be used only as directed by your healthcare provider. Opioid pain relievers can be addictive for both you and your baby. Talk with your pregnancy care provider about which migraine medicine can be used safely during pregnancy Sumatriptan succinate Warnings. May cause dizziness. May cause drowsiness. Alcohol and marijuana may intensify this effect. Use care when operating a vehicle, vessel (e.g., boat), or machinery. Protect from light Imitrex During Pregnancy and Breastfeeding. Tell your doctor if you are pregnant or plan to become pregnant while using Imitrex. It is unknown if Imitrex will harm a fetus. Your name may need to be listed on a sumatriptan pregnancy registry when you start using Imitrex. Imitrex passes into breast milk and may harm a nursing baby

Use of Triptans in Pregnanc

Sumatriptan is a drug that is used for treating migraine headaches.It belongs to a class of drugs called selective serotonin receptor agonists. Other members of this class include naratriptan (), zolmitriptan (), rizatriptan (), frovatriptan (), eletriptan (), and almotriptan ().. Migraine headaches are believed to result from dilatation of blood vessels in the brain Sumatriptan 100 mg film-coated tablets. 2. Qualitative and quantitative composition. Each 100 mg film coated tablet contains 140 mg sumatriptan succinate corresponding to 100 mg of sumatriptan. Excipient: lactose monohydrate 143 mg. For the full list of excipients, see section 6.1. 3. Pharmaceutical form


Sumatriptan injection comes as a solution (liquid) to inject subcutaneously (just under your skin). It is usually used at the first sign of a migraine headache. If your symptoms improve after you use sumatriptan but return after 1 hour or longer, you may use a second dose of sumatriptan. However, if your symptoms do not improve after you use. Tylenol (acetaminophen, or in Europe it is called paracetamol) is the go-to drug for pain, headaches, and fever during pregnancy. A new study just published in the journal JAMA Pediatrics indicates that this drug may not be as safe as previously thought.. Animal research has long suggested that acetaminophen is a so called hormone disruptor, a substance that changes the normal balance of hormones Imitrex (sumatriptan) is a triptan migraine medication used to treat the pain caused by migraines. Common side effects of Imitrex include pain or tightness in the chest or throat, tingling, flushing, weakness, dizziness, abdominal discomfort, sweating, nasal irritation, injection site reactions, and allergic reactions (rare). Consult your doctor before taking Imitrex if pregnant or breastfeeding UKTIS have produced a review regarding the fetal and. neonatal risks of exposure to treatments which. are being used to treat covid-19. Information regarding COVID-19 vaccine can be found. here ( Non-live vaccines) Ondansetron update. UKTIS Response Statement - Ondansetron Use in Pregnancy A pregnancy registry collected data from 1996 to 2012 about the health of babies who were exposed to sumatriptan (the active drug in Imitrex) during pregnancy. The information collected hasn't.

100-mg Tablets: Pink, triangular-shaped, film-coated, and debossed with IMITREX 100 on one side and a chevron shape (^) on the other.Each tablet contains 140 mg of sumatriptan succinate equivalent to 100 mg of sumatriptan antibiotic Only x pregnancy last month, X lactation. nitrofurantoin. Epilepsy drugs X pregnancy. Only safe migraine med in preg/lact. sumatriptan. Bromocriptine. X lactation. Amantadine. X lactation. Psych drugs X pregnancy. none. Antidepressants X lactation. fluoxetine, venlafaxine. cephalosporins. safe. tetracyclines. X pregnancy. gram. Sumatriptan This information from Lexicomp explains what you need to know about this medication, including what it's used for, how to take it, its side effects, and when to Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby

Pregnant or planning a pregnancy? For the active ingredient sumatriptan. You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy. Consumer Medicines Information (CMI) For side effects, taking other medicines and more. Print the CMI Common Trade Names: Imitrex; Adult Dosing. Intranasal spray: 5-20 mg, may repeat dose if headache persists after 2 hours; Oral: Initial: 50 to 100 mg once. If initial dose was partially effective or headache recurs, may repeat a dose (usually same as first dose) after ≥2 hours. Maximum dose: 100 mg per dose; 200 mg per 24 hours. Pediatric Dosin Sumatriptan oral tablets are available as both generic and brand-name drugs. Brand name: Imitrex. Sumatriptan also comes in a nasal spray, an injectable solution, or a nasal powder Pharmacor Sumatriptan are used to relieve a migraine attack. They should not be used to prevent migraine attacks from occurring. Pharmacor Sumatriptan may be used for migraine headaches with or without what is known as 'aura'. It is thought that migraine headache is due to widening of certain blood vessels in the head

The Women's Pregnancy and Breastfeeding Medicines Guide (PBMG) is a quick reference guide for healthcare professionals that provides practical and unbiased specialised information on medicine use in pregnancy and breastfeeding

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Sumatriptan is an anti-migraine drug with a chemical structure reminiscent of serotonin. It is the first discovered drug belonging to the family of triptans. Dosage. The safety and efficacy of sumatriptan have not been established. However, it can be given to children in the following dosage. Subcutaneous use: 6 m Tell your health professional if you are pregnant, planning to become pregnant, or breastfeeding. Tell your doctor if you need to use sumatriptan several times each week. Using sumatriptan too often can cause a different type of headache. Your doctor can talk with you about different medicines that are taken every day t 21 October 2020 · If simple analgesics, e.g. paracetamol and ibuprofen, are insufficient to treat symptoms, sumatriptan is the drug of choice for the treatment of acute migraine. Althoug