The AST/ALT ratio is the ratio between the concentrations of the enzymes aspartate transaminase (AST) and alanine transaminase, aka alanine aminotransferase (ALT) in the blood of a human or animal.It is measured with a blood test and is sometimes useful in medical diagnosis for elevated transaminases to differentiate between causes of liver damage, or hepatotoxicity An AST/ALT ratio higher than one (where the AST is higher than ALT) is suggestive of cirrhosis. An AST/ALT ratio higher than 2:1 (where the AST is more than twice as high as the ALT) is suggestive of alcoholic liver disease. However, a disease cannot be diagnosed by the pattern of elevation alone My liver ast level has been higher than my Alt level on three tests in the past year. 12/19 Ast 21 Alt 16. 5/20 Ast 23 Alt 18. And 8/20 Ast 18 Alt of 12. Does the ast alt ratio apply when within norma read mor The AST is typically in the 100 to 200 IU/L range, even in severe disease, and the ALT level may be normal, even in severe cases. The AST level is higher than the ALT level, and the ratio is greater than 2:1 in 70% of patients. A ratio greater than 3 is strongly indicative of alcoholic hepatitis
An AST/ALT ratio of 2.0 or higher or ALT level exceeding 300 U/L may be indicative of alcoholic liver disease. Your AST/ ALT ratio is normal. You are absolutely healthy and fine. Hope this helped. If you have any further question then you can ask me. Please leave positive rating above the chat box so I can get credit for helping you today The 2:1 ratio is suggestive of alcoholic liver disease especially in the presence of an elevated GGT. But not everyone with alcoholic liver disease has that ratio, only about 70 to 80 percent of people do. I certainly have well advanced alcoholic liver disease yet my ratio is 1.3:1. My Alt and Ast are also lower than yours The ratio of serum aspartate aminotransferase to alanine aminotransferase (AST/ALT ratio) has been proposed as a noninvasive method of assessing liver fibrosis and cirrhosis. Our aims were to confirm the usefulness of the AST/ALT ratio in diagnosing cirrhosis noninvasively as well as to verify the e The normal range for the ALT blood test is usually reported between 5-55 units per liter. The AST blood test has a normal range of 10-40 units per liter. Every laboratory has its own normal range, however, so certain results that fall outside of these reported norms may still be considered a normal result by some medical providers
1. Common causes of mild elevation of ALT and AST in an asymptomatic person. One of the most common causes of mild elevation of ALT and AST in asymptomatic persons is chronic alcohol consumption.2 This is a common finding even if the patient does not have alcoholic hepatitis or alcohol related liver cirrhosis or failure. If the AST:ALT ratio is greater than two, it is more suggestive of. While intense exercise increases ALT and AST in healthy people, in sedentary patients with chronic liver disease - including NASH (nonalcoholic steatohepatitis) - modest physical activity reduces elevated ALT levels caused by the liver disease.[22, 23] In addition, the blood ALT levels in people who exercise at customary levels are lower than. AST/ALT ratio (DRR) and associations with clinically relevant outcomes and mortality rates. We further divided patients by DRR to explore the relative mortality risk across the DRR strata (Table 2). Cumulative survival rates within 1 year across the DRR strata were 0.927, 0.898, 0.881, and 0.733 (p < 0.001)
This is so crazy. My blood is basically perfect and yet they have this thing flagged like I'm dying. I went through old bloodwork. In the past 13 years I have 10 blood tests from 6 different doctors. ALL show basically the same AST/ALT numbers. All within range (a couple times the ALT was slightly low). What the results DON'T show is a ratio Within the population studied, 87 percent of patients with an AST/ALT ratio of 1.3 or less had NASH (87 percent sensitivity, 84 percent specificity). 1999;94:1018-22. 8. Bayraktar M, Van. Background: Both ALT/AST ratio reversal (AST/ALT > 1) and prolonged prothrombin time are separately related to hepatic cirrhosis. Ratio reversal means that in normal individuals ALT is more than AST and thus ALT/AST > 1 but with development of cirrhosis AST becomes > ALT and so AST/ALT > 1 or ALT/AST < 1 Ask that a copy of the results be sent directly to you. Divide the AST number on your laboratory results by the ALT number to obtain the AST/ALT ratio. For instance, if your AST is 37 iu/L and your ALT is 22 iu/L, then your AST/ALT ratio is 37/22 = 1.68. Source. « Most Effective Beta Blockers for Frequent PVC's Nocturnal Seizure Signs. ALT = Alanine aminotransferase (S, U/L) *Ratio >2.0 suggests alcoholic liver disease. (AST= SGOT, ALT= SGPT). S= serum
Liver function tests are blood tests used to help diagnose and monitor liver disease or damage. The tests measure the levels of certain enzymes and proteins in your blood Ast / alt ratio - @Chris2055 - Liver disease - 20210727. Got a question been listening to all this mixed up information about ast/alt ratio thing. I talked to someone who asked there specialist about ast/alt ratio they told them they only worry about it if it's 2.0 he did not ask doctor what about if both ast /alt are normal . We further divided patients by DRR to explore the relative mortality risk across the DRR strata (Table 2).Cumulative survival rates within 1 year across the DRR strata were 0.927, 0.898, 0.881, and 0.733 (p < 0.001).Moreover, patients with higher DRR required MV and readmission within 1 year more often.
Elevated liver enzymes may indicate inflammation or damage to cells in the liver. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes, into the bloodstream, which can result in elevated liver enzymes on blood tests Reducing ALT or AST level is not possible in most cases, as elevated ALT levels normally indicate liver damage and elevated AST levels indicate tissue damage or damage to an organ such as the brain or heart, states WebMD. AST generally decreases on its own after injury, within days. ALT and AST testing are commonly done together, as both tests. AST is a protein made by liver cells. When liver cells are damaged, AST leaks out into the bloodstream and the level of AST in the blood becomes elevated. AST is different from ALT because AST is found in parts of the body other than the liver--including the heart, kidneys, muscles, and brain The AST to ALT Ratio is highly predictive of cirrhosis if ratio > 1 100% specificity and positive predictive value in distinguishing cirrhotic from non-cirrhotic patients, with a 53.2% sensitivity and 80.7% negative predictive value. DESCRIPTION. AST / ALT. FORMULA. The AST to ALT Ratio is highly predictive of cirrhosis if ratio > 1 100%.
Easily calculate the AST to ALT Ratio using AST and ALT values. Load Calculator. The ODX Software. The ODX Software Application is based on Dr. Weatherby's many years of research and practice in Functional Blood Chemistry Analysis. By combining a collection of rules, scoring, weighting, probability, uncertainty, and inference, Optimal DX has. The elevated AST-to-ALT ratio in alcoholic liver disease results in level is a typical finding in patients taking anticonvulsants and by itself does not necessarily indicate liver disease.22, 23 The normal AST/ALT ratio is approximately 0.8. An AST/ALT ratio of 2.0 or higher or ALT level exceeding 300 U/L may be indicative of alcoholic liver disease. However, the AST/ALT ratio is usually 1.0 or less in nonalcoholic fatty liver disease Our AST ALT ratio calculator is a simple tool that assesses the wellbeing of your liver. Don't worry - we'll do the calculations for you, and provide you with all the necessary information to interpret your results. In the article below, we will focus on alcoholic hepatitis in AST vs ALT calculations, we'll talk about different.
The AST/ALT ratio is the ratio between the concentrations of the enzymes aspartate transaminase (AST) and alanine transaminase, aka alanine aminotransferase (ALT) in the blood of a human or animal.It is measured with a blood test and is sometimes useful in medical diagnosis to differentiate between causes of liver damage, or hepatotoxicity.. Most causes of liver cell injury are associated with. An elevated serum AST in relation to serum ALT (alanine aminotransferase) has been proposed as an indicator that alcohol has induced organ damage. Thus, when AST/ALT ratio is >1.5, this is considered as highly suggestive that alcohol is the cause of the patient's liver injury (Correia et al., 1981; Salaspuro, 1987)
In alcoholic hepatitis, an ALT over 300 IU/l is rare, but increased AST/ALT ratio is often observed. In contrast, the AST/ALT ratio is low in non-alcoholic steatohepatitis , often accompanied by a modestly elevated GGT. Although there are many differential diagnoses for mild to modest elevations in ALT or AST, marked elevations are usually. The ALT and AST values won't necessarily be as high as expected for this. In practice for 20+ years, Dr. Blume treats over 65 conditions including abdominal pain, appetite loss, blood in stool, celiac disease, colon cancer, esophageal and liver disease, gas and IBS ALT levels are usually higher than AST. High AST/ALT ratio (>1.5) in acute viral hepatitis may be indicative of potential fulminant course.9 AST/ALT ratio greater than 1.0 in chronic liver diseases may be indicative of advanced fibrosis.8,9 AST and ALT are also used together with platelets to assess the likelihood of advanced live The mean AST/ALT ratio was 1.13 in PCa patients and 1.00 in BPH patients. ROC curve indicated that a AST/ALT ratio of 1.155 had maximum Youden index value (Figure 1) (sensitivity = 39.7%, Specificity = 78.4%); thus, patients with AST/ALT ratio < 1.155 had low risk of PCa, while patients with AST/ALT ratio > 1.155 had high risk of incident PCa
An increased AST/ALT ratio in patients with increased serum aminotransferase activity has also been associated with the development of cirrhosis in Nonalcoholic Steatohepatitis (Sorbi et al., 1999), even though a still higher AST/ALT ratio was observed in a group of non-biopsied patients with alcoholic liver disease The ratio of AST/ALT is also sometimes used as a marker of liver health. While ALT levels can signal the presence of liver damage, they cannot determine the type of damage, [22, 24] Chronic kidney disease [25, 26] Find out more about low ALT levels and associated conditions here AST/ALT ratio < 1 also had significantly lower HDL-C than subjects with AST /ALT ratio 1 (P <0.05). The level of FPG wa s similar between subjects with AST/ALT ratio < 1 and 1 (P >0.05).(Table 1) Associations of AST/ALT ratio with anthropometric and metabolic variables were presented in Table 2
Normal value of ALT isÂ 7 to 55 units per liter (U/L). Aspartate transaminase (AST).Â AST is an enzyme that helps metabolize alanine, an amino acid. Like ALT, AST is normally present in blood at low levels. An increase in AST levels may indicate liver damage or disease or muscle damage. Normal value of AST is 8 to 48 U/L An AST/ALT ratio may be calculated to aid in distinguishing between different causes and severity of liver injury and to help distinguish liver injury from damage to heart or muscles. The AST/ALT ratio is typically > 1 in alcoholic liver disease and AST/ALT < 1 in non-alcoholic liver disease As far as I know, it is the ratio of AST/ALT that is important. Since I read (see below) of the ratio of AST/ALT, I have been tracking it as one of several biomarkers to assess how well I am doing - my bladder cancer is one that is known for its h.. . The ratio is less useful in scenarios where the liver enzymes are not elevated, or where multiple conditions co-exist.In most types of liver disease, the ALT level is higher than AST and the AST/ALT ratio is a value less than 1.0 Normal values are about 9.5 to 13.8 seconds. Albumin level (hypoalbuminemia): Albumin is a very common protein found in the blood with a variety of functions. It also is produced only in the liver, and if its levels are lower than normal it can be suggestive of chronic liver disease or liver cirrhosis
A calculated AST/ALT ratio is useful for differentiating between different causes of liver injury and in recognizing when the increased levels may be coming from another source, such as heart or muscle injury. The AST/ALT ratio is typically > 1 in alcoholic liver disease and AST/ALT < 1 in non-alcoholic liver disease To assess the AST/ALT ratio on poor prognosis of patients with different liver enzyme levels 23, we separated the 555 COVID-19 patients with clear survival data (recovery or death) into two groups. Elevated liver enzymes usually are not a life-threatening condition, but high ALT and AST do warrant prompt medical attention. Chronic liver disease and cirrhosis caused more than 39,000 deaths in the United States in 2005, according to the Centers for Disease Control and Prevention, as well as the hospitalization of about 112,000 people 1. Elevated ALT and AST indicate damage to your liver. My AST is 24 and my ALT is 24. I read in an Oxford Journal that 'most patients with high alcohol consumption but without severe liver disease do not have an AST/ALT ratio above 1.' AST=24 and ALT=24 were my last lab results. In September, 2004, AST=17 and ALT=24. I have no out-of-range lab results (other tha
The usual treatment for high ALT is to first determine the cause, and then remove it, e.g. to use anti-viral medications, go on a weight loss diet or stop drinking, etc. As the liver has good self-recovery ability, quite often when the cause is removed, it heals itself and ALT level lowers. But in some cases, removing the cause might be. Aspartate aminotransferase (AST) is an enzyme normally found in your liver, heart, pancreas, kidneys, muscles and red blood cells. Very little AST is normally circulating in your blood (between 0 - 42 U/L), but levels become elevated when your organs or muscles are damaged — from liver disease, a heart attack or car accident, for examples. An AST blood test is often done in conjunction. Mild ALT and AST elevations (ALT and AST less than 5 times the upper limit of normal (ULN)) should be rechecked before extensive work-up is undertaken. Possible causes: chronic hepatitis C or B, acute viral hepatitis, NAFLD , hemachromatosis, autoimmune hepatitis, medications, alcohol-related liver injury, Wilson's disease
In detail, 10 of the 35 patients with an AST/ALT ratio > 75th percentile had an ORR of 29%, compared with 51 objective responses in the 108 patients with an AST/ALT ratio lower than or equal to this cutoff (ORR = 47%), for an absolute difference in response of 19% (95% CI: 0-36, p = 0.039, Figure 1) The AST/ALT ratio is the ratio between the concentrations of the enzymes aspartate transaminase (AST) and alanine transaminase (ALT) in the blood. Known as De Ritas ratio. Generally, the cutoff value is 1.24: with levels 1.24 or above the the ratio AST/ALT is high, and <1.24 ratio is low The AST:ALT ratio was designated as a hemolytic marker, and simple and multivariate regression analyses were carried out between this ratio and other hemolytic markers. Results: Mean AST and ALT levels were 48.24 ± 27.78 and 26.48 ± 22.73 U/L, respectively Objective . To investigate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), and coronary artery aneurysms (CAA) in children with Kawasaki disease (KD). Design . We retrospectively studied 2678 children with KD and divided them into two groups: a.
The AST/ALT ratio, also termed the De Ritis ratio, is used to di erentiate varying causes of liver disease and has also been proven to be a useful biomarker in many non-hepatic diseases . Cumulating evidence suggests that the AST/ALT ratio might represent an independent prognostic factor in several cancer entities [12-16] It is always advisable to consult a medical practitioner who will explain to you the meaning of your result. The normal range of the AST level is given below. Male. 10-40 units/L. Female. 9-32 units/L. On average, the AST level in women is slightly lower than men Objective Aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio, reflecting liver disease severity, has been associated with increased risk of cardiovascular disease (CVD). The aim of this study was to evaluate whether the AST/ALT ratio improves established risk prediction tools in a primary care population. Methods Data were analysed from a prospective cohort of 29 316 UK. The characteristics of study participants according to the speed of eating are shown in Tables 1 and 2.ALT was significantly higher in the eating quickly group than in the not eating quickly group for both men (p < 0.01) and women (p < 0.01).On the other hand, the AST/ALT ratio was significantly lower in the eating quickly group than in the not eating quickly group for both men (p < 0.01) and.
The AST:ALT ratio (De Ritis ratio) can be used to determine alcohol-induced liver disease, with AST:ALT ratio greater than 2. Elevated AST and normal ALT can indicate a normal liver but damage to other organs and/or hemolysis. Both AST and ALT are dependent on vitamin B6 (pyridoxal phosphate). Assays for AST and ALT assume adequate levels of. Blood tests for liver diseas I recently had my liver enzymes tested at a health fair and the results were ALT 22 iu/L and AST 37 iu/L . I was told these are abnormal and I am now so scared and know I need to quit consuming alcohol altogether. From what I understand, the ALT is within normal range and the AST is slightly elevated, but the ratio is most concerning
The treatment-naïve and treatment groups showed significantly higher serum AST:ALT ratio, and lower log10ferrtin:AST ratio than the healthy controls. 22(12):1978-83. CAS PubMed Article Google Scholar 14. Armengou A, Davalos A. A review of the state of research into the role of iron in stroke. J Nutr Health Aging. 2002;6(3):207-8.. AST and ALT are normally found in low levels in the serum (<30-40 IU/L) and levels in higher concentrations are a sensitive marker of liver injury [ 5 ]. The AST and ALT vary with age. In children, the AST is typically slightly higher than the ALT, but this ratio reverses in adulthood with a typical AAR of 0.8 [ 6, 7 ] Question: Does the ast/alt ratio matter when levels are in the normal range? I had an echogenic liver impression fatty liver on ultrasound months ago.I was a heavy drinker at the time and had been for several years. At the time ast 22 and alt 18. THough ratio off, normal range, other labs normal as well
Table 4 shows the association of the combination of low AST/ALT ratio and elevated GGT with CKD. Compared to AST/ALT ratio ≥ 1 and non-elevated GGT, AST/ALT ratio < 1 and elevated GGT (OR: 2.73, 95% CI: 2.36-3.15) and AST/ALT ratio ≥ 1 and elevated GGT (2.33, 1.98-2.75) were significantly associated with CKD An AST:ALT ratio of ≥2:1 is suggestive (≥3:1 highly suggestive) of ALD. 6,10,11 The relatively low ALT level in patients with ALD is caused by depletion of pyridoxine (vitamin B 6), which is used as a coenzyme in the synthesis of both AST and ALT. 12 ALT synthesis, however, is more affected than AST synthesis. Alcohol also induces. They showed I had High levels in 3 tests that point to liver issues, as best I can tell. Here they are: GGT of 207 (3-85 is normal) AST (SGOT) is 87 (10-35 is normal) ALT (SGPT) is 94 (9-60 is normal) My on-line research indicates that the ratio (0 replies) AST/ALT high, Rest are Normal. Aug 28, 2006 ALT (sensitivity 96%, specificity 94%). 3 In uncomplicated alcoholic hepatitis, AST and ALT values are almost never over 10× the upper reference limit, while AST/ALT ratio is over 2 in 80%.4,5 Other liver diseases are sometimes encountered as the causes of acute increase of AST or ALT activities; in a recent study, 25% of those with AST more. * AST/ALT mneumonic #307186 : okt3 - 06/01/08 22:04 : AST (SGOT) is increased in: A M-E-S-S-I-A-N-I-C L-A-M-B F-R-O-M God A-Alcoholic hepatitis: The AST / ALT ratio i
AST: ALT ratio of 3. Erinn1978. Hi-. I'm a generally healthy 32 year old female but I just had a regular doctor's visit and got my test results today. My AST is 33 and my ALT is 11. I looked at my tests over the past few years and it seems I've always had a 2:1 ratio of AST to ALT but all numbers were always in a normal range In both genders with a BMI of 22.0 to 25.0 kg/m 2, AST/ALT ratio was a reliable marker of insulin resistance, but in subjects with a BMI of <22.0 kg/m 2, AST/ALT ratio was not significantly associated with HOMA-IR. Table 6 Association between ALT/AST ratio and insulin resistance (HOMA-IR ≥2.5) and HOMA. Elevated AST. Normal serum AST is 14-20 IU per liter in men and 10-36 IU per liter in women.When a blood test for AST indicates elevation above normal range, the indication is that damage may be present to one of the organs where AST is normally found.. Elevated AST can be an indicator of liver disease, heart and cardiovascular disease, damage to the skeletal muscles, severe burns, severe loss. The AST/ALT ratio had 81.3% sensitivity and 55.3% specificity in identifying cirrhotic patients who died within 1-year of follow-up. Conclusions The AST/ALT ratio is both reproducible and transportable in patients with HCV-related CLD. The AST/ALT ratio is correlated with both histologic stage and clinical evaluation Limitations of AST/ALT ratio in paracetamol poisoning To the Editor: W e read with interest the article by McGovern et al. in which they studied the ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) when examining recovery from paracetamol poisoning in 37 patients, and determin
Data on study variables, including demographic data, left ventricular ejection fraction, NYHA class, and AST/ALT ratio, were collected from patients' records. The patients were divided into two groups, namely group-1 (AST/ALT ratio < 1) and group-2 (AST/ALT ratio ≥ 1), to identify any differences in their cardiac function profiles Recently, the De Ritis (AST/ALT) ratio has been considered as a prognostic biomarker for various malignancies. We conducted this systematic review and meta-analysis to explore the prognostic value of preoperative De Ritis ratio in patients after surgery for urothelial carcinoma. We searched the online database Embase, PubMed and Cochrane Library up to October 2019 Twenty‐six patients with minimal necroinflammatory activity (Knodell score 0-4) had an AST/ALT ratio of 0.60±0.23, 17 patients with mild necroinflammatory activity (Knodell score 5-8) had an AST/ALT ratio of 0.59±0.15, and six patients with moderate necroinflammatory activity (Knodell score 9-12) had an AST/ALT ratio of 0.63±0.18
In fact, if AST levels are abnormal and ALT levels are normal, the problem is much more likely due to a heart condition or muscle problem rather than the liver. In some cases, the AST-to-ALT ratio. Analyzing AST/ALT ratio for any significant association with the histopathological variables, patients with renal vein invasion (n=18), renal capsule infiltration (n=34), and renal pelvis involvement (n=30) were found to have a significantly higher AST/ALT ratio (p=0.013, p=0.049, p=0.004, respectively)
The aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio has been proven to be such an indicator of cirrhosis in alcoholic liver disease, hepatitis C. Aim: To test whether the AST/ALT ratio is a marker of cirrhosis also in patients with primary biliary cirrhosis (PBC). Methods: The study consisted of 160 patients. In 126 patients. AST (aspartate aminotransferase) is an enzyme that is found mostly in the liver, but also in muscles. When your liver is damaged, it releases AST into your bloodstream. An AST blood test measures the amount of AST in your blood. The test can help your health care provider diagnose liver damage or disease. Other names: SGOT test, serum glutamic. One 2003 study showed that hepatitis C patients who drank coffee daily were 3x more likely to have regular ALT levels versus non-coffee drinkers. Meanwhile, a 2017 study review showed that drinking up to 4 cups of coffee/day could help to lower ALT levels and also lower chance cancer and liver disease to produce low ast levels of blood causes
The mean AST/ALT ratio in the cirrhotic patients (n = 47) was higher than in the noncirrhotic patients (n = 92) (1.06 ± 0.06 vs 0.60 ± 0.09; p < 0.001). A ratio ≥1 had 100% specificity and positive predictive value in distinguishing cirrhotic from noncirrhotic patients, with a 53.2% sensitivity and 80.7% negative predictive value In a multivariable adjusted model, the odds ratio (95% confidence interval) for new onset of metabolic syndrome, comparing the fourth quartile to the first quartile of the AST-to-ALT ratio, was 0.598 (0.422-0.853). The AST-to-ALT ratio also improved the area under the receiver operating characteristic curve (AUC) for predicting new cases of. Need for validation of clinical decision aids: use of the AST/ALT ratio in predicting cirrhosis in chronic hepatitis C Published in: American Journal of Gastroenterology, September 2000 DOI: 10.1111/j.1572-0241.2000.02322.x: Authors: Thomas F. Imperiale, Areen T. Said, Oscar W. Cummings, Lawrence J. Bor The ratio of AST to ALT in plasma may help in the diagnosis of some liver diseases. Most liver diseases are associated with greater elevation of ALT than AST because of differences in the circulating half-life of each enzyme and the cellular distribution. ALT has a longer circulating half-life (47+/- 10 hours) than AST (17+/-5 hours).. De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke Fan Gao,1 Chen Chen,2 Jun Lu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, 2Department of Neurology, 3Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China Purpose: The.
International normalized ratio (INR) is blood-clotting test. It is a test used to measure how quickly your blood forms a clot, compared with normal clotting time. Explanation of test results: A normal INR is 1.0. Each increase of 0.1 means the blood is slightly thinner (it takes longer to clot). INR is related to the prothrombin time (PT) In the non-centrally obese subjects, the ALT/AST ratio had comparable power to identify IR as those of BMI [AUC 0.64(0.63-0.66); vs AUC of the ALT/AST ratio, P = 0.22] and TG [AUC 0.64(0.63-0.66); vs AUC of the ALT/AST ratio, P = 0.21], while in the centrally obese subjects, the ALT/AST ratio had the greatest power. However, the ALT/AST. Elevated liver chemistries are common, with multiple proposed evaluation algorithms to investigate an extensive differential diagnosis. One simple and inexpensive set of laboratory parameters which can guide the evaluation of elevated liver chemistries and is often overlooked is the AST to ALT ratio (AAR). Immediately available, this simple ratio can offer important clues to the underlying. Results: The mean AST/ALT ratio in the cirrhotic patients (n = 47) was higher than in the noncirrhotic patients (n = 92) (1.06 ± 0.06 vs 0.60 ± 0.09; p < 0.001). A ratio ≥1 had 100% specificity and positive predictive value in distinguishing cirrhotic from noncirrhotic patients, with a 53.2% sensitivity and 80.7% negative predictive value..
The aspartate aminotransferase (AST) test is a blood test that checks for liver damage. Your doctor might order this test to find out if you have liver disease and to monitor your treatment.. Your. ALT is more concentrated in the liver, so if AST is high while ALT is normal, it can be a sign of a problem outside the liver. In other cases, though, having a much higher level of AST than ALT can be a sign of alcohol-induced damage to the liver. It is also important to note that, by itself, having elevated AST is not proof of a medical problem A normal result for AST is below 40 IU/L in both males and females. If an infant or young child is being tested, the values may be slightly higher due to their age. Like ALT, a low AST value means that your liver is functioning properly and there is likely no cause for alarm. a low AST range does not indicate disease The ratio of serum alanine aminotransferase to serum aspartate aminotransferase; elevated serum levels of both enzymes characterize hepatic disease; when both levels are abnormally elevated and the ALT:AST ratio is greater than 1.0, severe hepatic necrosis or alcoholic hepatic disease is likely; when the ratio is less than 1.0, an acute nonalcoholic hepatic condition is favored